Scientists Cast Doubt on Alzheimer’s Cancer Drug Study

Jakarta Globe, Agence France-Presse, May 27, 2013

One hemisphere of a healthy brain, left, is pictured next to one hemisphere
 of a brain of a person suffering from Alzheimer disease. (Reuters Photo/
Denis Balibouse)

Washington. Four separate teams of scientists have said they were unable to replicate a highly publicized study that last year touted a cancer drug’s success against Alzheimer’s disease in mice.

“We wanted to repeat the study to see if we could build on it, and we couldn’t,” said David Borchelt, a professor of neuroscience at the University of Florida, noting that “it was important to publish the fact.”

“Maybe there should be some caution going forward in regard to patients,” he added.

The high profile 2012 study in the US journal Science found that mice treated with bexarotene became rapidly smarter and the plaque in their brains that was causing Alzheimer’s started to disappear within hours.

The drug was believed to work by boosting levels of a protein, Apolipoprotein E (ApoE), that helps clear amyloid plaque buildup in the brain, a key hallmark of Alzheimer’s disease.

“We were shocked and amazed,” lead author Gary Landreth, a professor in the Department of Neurosciences at Case Western Reserve University School of Medicine in Ohio, told AFP when the study was published in February 2012.

“Things like this had never, ever been seen before,” he said.

But a key part of science is being able to replicate the findings of any research, and international researchers reported in four separate papers in Science’s May 24 edition that they had failed to do so.

Other researchers who published their attempts were Bart De Strooper, director of the VIB Center for the Biology of Disease in Belgium, and Sangram Sisodia, director of the Center for Molecular Neurobiology at the University of Chicago.

The scientists said their studies showed no effect on the plaque levels in three different populations of lab mice treated with bexarotene.

A fourth group of researchers said they observed mental gains in the mice but could not confirm they were achieved by the mechanism initially reported, said co-author Iliya Lefterov, associate professor at the University of Pittsburgh Graduate School of Public Health.

“While we were able to verify that the mice quickly regained their lost cognitive skills and confirmed the decrease in amyloid beta peptides in the interstitial fluid that surrounds brain cells, we did not find any evidence that the drug cleared the plaques from their brains.”

The findings should also serve as a warning for doctors not to prescribe bexarotene as an off-label treatment for Alzheimer’s, researchers said.

The drug, also known as Targretin, was approved by the US Food and Drug Administration in 1999 for treating a type of skin cancer known as refractory cutaneous T-cell lymphoma.

“Anecdotally, we have all heard that physicians are treating their Alzheimer’s patients with bexarotene, a cancer drug with severe side effects,” said Robert Vassar, professor of cell and molecular biology at Northwestern University Feinberg School of Medicine.

“This practice should be ended immediately, given the failure of three independent research groups to replicate the plaque-lowering effects of bexarotene.”

Agence France-Presse

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You are Multidimensional - Celebrate Your Life! -  6 April 2008 (a message from Goddess of Creation channeled by Shelly Dressel)

Question: Why are so many new humans developing autism at this time?  Is there a purpose? Is there something we can do to assist them?  And then in addition to that, is there a correlation between autism and Alzheimer's?

Goddess: Autism is very much on people's mind at this time upon the earth.  It is a term that has been given to many children.  It is a definition that people give to a child as a means of trying to understand their behavior or how they think or how they are within their life.  Autism as you know it right now is but a fraction of what it truly is going to indicate in the future.  Many of the individuals that are being termed autistic are not necessarily autistic.  Autism in and of itself is a disconnection within.  Or you could say it's that these people have a different way of being able to communicate from others around them.  So when we say disconnect, it's not that they have fully disconnected with the other individuals; it's just that they are vibrating and living and experiencing life on a different level or a different plane.

Many have said that those who are autistic have their feet in two different dimensions or in multiple dimensions; yes, that is true.  Many have said that those children who are autistic have a short in their wiring as if there are aspects that are not working in this individual and this I would like to disagree with.  What's happening is, you are getting children especially who are of very high vibrations that are incorporating more of the crystalline vibration and less of the dense energies that have been upon the earth for the last several thousand years.

Therefore the electrical impulses that move through a crystal as opposed to the electrical impulses that move through a regular individual we shall just say or someone with regular wiring, there's going to be much less resistance, therefore their whole metabolism, everything about them is functioning on a completely different basis.

This journey tonight was to assist each one of you in recognizing just how much you are moving between dimensions.  These children that come in with these special gifts are used to moving (between dimensions) and they do it unconsciously.  To them, their sense of awareness, their sense of reality is very different from your own.  They may live in other realities while their physical body is here upon the earth.  Provide them with the structure that they may need to be able to function in society but also recognize that these are highly evolved individuals and respect that about them.

There may be crystals, there may be colors, there may be vibrations, things that emanate a vibration that assist the children in feeling more comfortable in their skin, in their reality.  If you are one of the individuals that would like to work with them or you find yourself perhaps having a child with these symptoms, go and open your senses and communicate from that of an expanded consciousness from the fifth, sixth or even seventh dimension.  Communicate from your heart, communicate without words, communicate through feelings and energies and you will find there's a great deal of information they are sharing with you.  These children are extremely sensitive so be aware of that and what is in their environment.

When it comes to Alzheimer's, there are some parallel pathways that one could point out.  Alzheimer's is a means of an individual beginning to cross over, beginning that journey back to this side of the veil but they have not yet fully chosen to return so they move at their own pace, experiencing whatever it is that they seek to experience.  And that is one reason why Alzheimer's seems to affect people for years at a time.  So while there are some similarities, that's as far as that goes.  Alzheimer's is a time to love and nurture an individual and again accept that this is their choice and this is their path.

Towards the end they are spending more and more of their reality in this other dimension.  For some it's a means of allowing them to feel comfortable with where they are going before they transition.  What you can do with them is also communicate from the heart, communicate without words. Assist them in being comfortable in other vibrations and assist them in being comfortable with the light and they will transition when the time is right for them.

I knew that this was something that was affecting many, many people and that is why I chose to give it a little bit more time and connection, and I thank you all for your patience.

Kryon Q&A

Question: Dear Kryon: I've just read the question about what happens as our earth body dies, and I'd like to add another issue: What happens during some diseases as Alzheimer disease, what happens to our spiritual body during the loss of memory, or when our earth body works as a vegetable?

Answer: This very year we have addressed the fact that you are actually "multiple entities." All of you! When what you call normal Human consciousness leaves the body through disease or injury, this "spark of divinity" you call the personality, is transferred to what you call The Higher-Self. No energy is every destroyed. Instead, it just moves somewhere else. Therefore that life that is in limbo is there for YOUR lesson, not theirs. They have elected this path (believe it or not), and now are here holding space for you and others in a less than aware state. But for them? They are already over here. . . celebrating and loving you for your service to them!

Question: Dearest Kryon: I've read the question and answer on people with diseases of the mind - for example, Alzheimers and dementia. But I have more questions. You say that people have chosen this path and that the lessons are for us. As I work with these people, I'm wondering if there is any stage where there could be a reversal of the condition, and if so, with what methods? The people in the hostel are so drugged up, and there's a mind-set with the authorities that no "alternate" therapies work - although they're using colored lights. (Sadly, the diversional therapist told me she doesn't know what color therapy is.)

From a spiritual point of view, what is the best way to work with these people - talk to them as though they were normal, or go along with their imaginings? I've been told that they need to be kept quiet, especially toward evening. However, I've found that with one woman who mostly paces saying very little, the more childlike I am (dancing and singing makes her happy), the more she talks. I could go on and on - could you please enlighten me further?

Answer: I will answer the second part first. Love those who are in this condition. Find out what makes them smile... and then make them smile. The best you can do in a facilitation of this condition is to somehow create joy. Even in their confusion they can laugh at situations and be creative. They'll also remember you better as the one who creates this emotion. Each is very different, but in general, try to find their "happy" button and push it as often as you can. They will remember that.

Right now you're perched upon some important discoveries that will be able to reverse these conditions to a large degree. But just as the paraplegic who regains their nerve connections must than relearn how to walk, suffering much pain, there will be this attribute with a regeneration of the mind. Even if new cells are created, they won't necessarily have the old memories, but they can be trained to be healthy and be ready for new memories.

So someday these will have the ability to halt the progress of the degeneration of cells that are being taken, and instead grow new pathways around them. Some will be able to "reconnect" to certain kinds of memories (like recognition) but will have to relearn what the association of recognition actually means. So history and events might have to be studied and relearned... sometimes even things like reading, also. The pain will be that the individual will regain mental health and will realize exactly what has happened.

Your stem-cell research is very important, and you're reaching a point where you'll be able to use birth cells that aren't embryonic, but every bit as potent for research... thereby sidestepping all moral issues. Look for this in the next few years. 

"THE THREE WINDS" – Feb 23-24, 2013 (Kryon Channelling by Lee Caroll) (Subjects: Humanity, Home - other side of the veil, Wind of Birth - Birth, Wind of Existence - Life, Wind of Transition - Death)

"Viewing the Other Side of the Veil" - January 7, 2007 (Kryon Channelling by Lee Caroll) - (Text Version)