Yahoo – AFP, Marlowe Hood, April 11, 2016
Paris (AFP) - Scientists said Monday they had found a handful of healthy people each carrying a genetic mutation that should have condemned them to crippling disease or death.
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| Scientists researched the genomes of nearly 600,000 normal people for telltale mutations leading to any of hundreds of distinct genetic diseases (AFP Photo/ Georges Gobet) |
Paris (AFP) - Scientists said Monday they had found a handful of healthy people each carrying a genetic mutation that should have condemned them to crippling disease or death.
The
discovery, made by scanning the genomes of nearly 600,000 normal people, opens
up a new approach to finding treatments for cystic fibrosis and dozens of other
rare and incurable conditions linked to specific variations in a single gene.
Up to now,
medical science assumed that anyone unlucky enough to have one of these
so-called Mendelian mutations -- named after the 19th-century founder of modern
genetics -- was doomed.
"Most
genomic studies focus on finding the cause of a disease, but we see tremendous
opportunity in figuring out what keeps people healthy," said Eric Schadt,
a professor at the Icahn School of Medicine in New York City, and a main
architect of the study.
"Millions
of years of evolution have produced far more protective mechanisms than we
currently understand," he said in a statement.
Together
with colleagues Stephen Friend and Rong Chen, Schadt led a team of 30
researchers in sifting through data on nearly 900 genes from each person's
genome, looking for the telltale mutations leading to any of hundreds of
distinct genetic diseases.
A rigorous
process of winnowing left them with 13 individuals who had gene variants that
would normally result in one of eight debilitating conditions.
Besides
cystic fibrosis, which inflicts severe damage on the lungs and the digestive system,
these included Pfeiffer syndrome, characterised by a severe deformation of
skull bones, and Smith-Lemli-Opitz syndrome, a disorder linked to multiple
malformations and intellectual disability.
The results
were published in Nature Biotechnology.
"These
rare individuals must possess some combination of factors -- genetic or
environmental -- that protects them from an otherwise crippling disease,"
Daniel MacArthur, a genomics researcher at Massachusetts General Hospital who
was not involved in the study, commented in the same journal.
The next
step would be to locate enough cases of people who have survived to adulthood
despite these genetic flaws to identify -- and eventually duplicate -- these
protective mechanisms.
'Genetic
superheros'
Until
recently, it would have been technically unfeasible to scan hundreds of
thousands of human genomes in this manner.
"This
study demonstrates the power of using big data to ask new biological
questions," said Anne Wojcicki, co-founder and CEO of personal genomics
company 23andMe, which participated in the project by providing access to data
on more than 400,000 of its customers.
In a
frustrating twist, however, the researchers were unable to follow up with any
of the 13 people found because of limitations in the consent policies they had
signed.
Experts
commenting on the study said this was a regretable shortcoming that limited the
value of the findings and would need to be changed in future research.
"Some
of the patients may have had disease that went unreported," said Scott
Hebbring, a scientist at the Marshfield Clinic Research Foundation and a
professor at the University of Wisconsin.
Ada Hamosh,
clinical director of the McKusick-Nathans Institute of Genetic Medicine at
Johns Hopkins University, said mutation for cystic fibrosis were so unlikely in
healthy people that the results may have stemmed from a "technical
error."
The two
cases of Pfeiffer syndrome, he added, could have been so mild as to not be
detected as such.
But
commentators agreed that the idea of scanning large populations to find
individuals who are healthy despite carrying gene variants known to cause
disease holds great promise.
"Achieving
this goal will require incredibly large sample sizes," measured in
millions not thousands, said MacArthur.
It will
also need what he called "genetic superheros" to step up and dotate
their genomic and clinical data so researchers can pick through them.
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“.. Mining the Akash - The Role of Innate
What I'm going to tell next, we have given you before. However, I wish to explain it better in this communication. Your innate is also a governor of what you personally need. Let me explain: Turn a page with me. We have talked in the past about mining the Akash. So let us open that door for a moment. Is it possible, dear one, that you could go into the vast storehouse of the attributes of your past lives and pick out something that you need today? The answer is yes. It's called mining the Akash, and it is a staple of the Kryon teaching. However, the way it's accomplished by the individual Human is really difficult to describe. It's a personal intuitive process. However, one attribute of it that is often misunderstood is that permission from the innate is needed. This is because the innate smart body knows what you need. It is then the governor, or the filter, giving you permission regarding what can be pulled out of your Akash and used. It will say no to frivolous things and yes to the things that will allow you to cure yourself of disease, live longer, and increase the efficiency of your DNA. It's a smart body regulator.
Innate doesn't care how you look. It cares about your health. If you want to go into your Akash and pull out something that you need for survival, it's right there with you. If you want to make clearer skin, it won't respond. Do you see what I mean? It's the governor for mining the Akash. By the way, the Akash is very ready to be used for this. [Kryon wink]
You have earned what you've lived, dear ones, and it's very available. It lies in a quantum soup of lifetime information that is ready to be used. If you have a disease in your body right now, and perhaps you want to mine the Akash in a way that will create healing, you can. Like all nonlinear things, it requires a new, mature consciousness and practice to work. But the body is ready for you to "go get" the cellular structure of a past life that had no disease. The blueprint for this resides within you since you earned it and lived it. The innate is responsible for spontaneous remission! Science has no idea how a Human does this. The innate can help you "go get" the things within your earned Akash and place them into your cellular structure. That's how smart it is! Imagine clearing disease so completely that there is no sign it was ever there? It happens all the time. Imagine being able to drop a chemical dependency overnight? It's exactly the same principle.
Did you ever sit in a meeting and something is said or a feeling can happen, and you get chills? What are they? You might say, "They are chills of validation." Guess where they came from? The innate! The innate has the ability to signal you the truth. The brain does not. In fact, your brain will often get in the way. It's the brain that contains your box of belief. It's the brain that contains the perception of who you are based on experience and memory. It's your 3D survival instrument. But the brain can't give truth. It can only give you what it perceives as the truth, based on logical, processed, computed, synaptic reasoning and only based on your past experience.
Your brain can tell you not to touch the stove because of what happened once before. But it can't give you chills of validation from information it does not have. The intellect wants you to believe that your brain is supreme. However, the brain is only one part of the body system and not a very intuitive part. It is the innate that knows the truth. The innate is connected to the quantum parts of your DNA and, therefore, also knows of your spirituality and the truth of God inside. …”
Your brain can tell you not to touch the stove because of what happened once before. But it can't give you chills of validation from information it does not have. The intellect wants you to believe that your brain is supreme. However, the brain is only one part of the body system and not a very intuitive part. It is the innate that knows the truth. The innate is connected to the quantum parts of your DNA and, therefore, also knows of your spirituality and the truth of God inside. …”
“… Biology and Intent
Let's talk more about biology because now it gets a little more complex. There is an intermingling of the 3D and the quantum that we wish to describe to you now. It's something that is new, for the vibration of this planet and of humanity, especially of those who are working with the light, is creating a new tool set. You're going to start to see it and it's going to be visible through examination of the 3D chemistry of DNA, even at the 3D level.
Science is now looking at what they call markers in the protein-encoded DNA, which creates the Human genes. These markers, as they are described by science, are those that are the pieces and parts that would indicate predispositions - attributes that might weaken certain cells so that later in life they would allow disease, such as cancer. They're starting to see these markers, perhaps in certain families where mothers and daughters and their daughters and their daughters all had the same kind of disease. They're starting to see the genetic markers that create predisposed weakness.
Let's talk about the markers, for this is the first time we have disclosed this. First the premise: For years we have told you that your intent to talk to your cellular structure has power. This intent is your communication to the DNA field to alter something within the 3D cellular structure. You might say it's your own interdimensional "voice" giving instructions to the quantum part of your DNA, which then results in the actual chemical changes that are occurring in the codes within your 3D genome. But now the results are going to be seen, and you can begin by removing the markers, and when you do, they stay removed. This means that something quantum you do today can change the chemistry of your gene-producing DNA so greatly that it will NOT be passed to your children. You can break the chain.
Blessed are the Human Beings who realize that as they purify their lives with the light of the Creator, it will affect the biology of the protein-encoded parts. You can erase the markers. It's one of the first times that the 3D has intermingled with the quantum so that science can someday look at the same Human Being over time, knowing that DNA never changes... yet it did! It's yours and it's unique and you changed it. There will be no answer for them, but the 3D facts will show it, that you eliminated the marker.
The joy of this and the beauty of this is that the lineage of the young women who do this will be shown, for their daughters will not have the disease, nor will the daughters of their daughters. It's a new gift and reflects the power of the times. Can you really change those who are your children-to-be? Indeed!
I know what you are thinking. The crowd who sits here says, "Well, it's a little late, Kryon. I've had my children. So why do you sit here and tell me these things?" Are you not understanding where this message is going? Are you not understanding the profundity of what happens when old souls allow us to give this information to Earth? Do you not understand your energy has generated the allotment of allowance for us to come in today and give you this, so that young women and young men who are Lightworkers each will hear it and know what it means to them? Do you understand you're your own ancestors? Has this occurred to you? I see you as actual history, sitting in the chair, from all over the world! That's what I wanted to tell you today.
You don't each have one name to me. I don't even see the gender that you are. I see you in a quantum state and that's why it's so profound that you would let us come in and visit you in this fashion. The woman sits in the chair in front of me. She has no idea the warrior she's been, or how big she was when she was a man. Yet she carries around with her the feeling of the warrior and she knows she's strong. I look at the big, burly man and I see the mother toiling with all those children and the man knows it. He can feel it. He's sensitive and can actually feel the love of a mother. Who is it he used to be? And how has it affected him today? ..."
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