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The resulting mice were fully fertile |
Stem cells
made from skin have become "grandparents" after generations of life
were created in experiments by scientists in Japan.
The cells
were used to create eggs, which were fertilised to produce baby mice. These
later had their own babies.
If the
technique could be adapted for people, it could help infertile couples have
children and even allow women to overcome the menopause.
But experts
say many scientific and ethical hurdles must be overcome.
Healthy and
fertile
Stem cells
are able to become any other type of cell in the body from blood to bone, nerves
to skin.
Last year
the team at Kyoto University managed to make viable sperm from stem cells. Now
they have performed a similar feat with eggs.
They used
stem cells from two sources: those collected from an embryo and skin-like cells
which were reprogrammed into becoming stem cells.
The first
step, reported in the journal Science, was to turn the stem cells into early
versions of eggs.
A
"reconstituted ovary" was then built by surrounding the early eggs
with other types of supporting cells which are normally found in an ovary. This
was transplanted into female mice.
Surrounding
the eggs in this environment helped them to mature.
IVF
techniques were used to collect the eggs, fertilise them with sperm from a male
mouse and implant the fertilised egg into a surrogate mother.
Dr
Katsuhiko Hayashi, from Kyoto University, told the BBC: "They develop to
be healthy and fertile offspring."
Those
babies then had babies of their own, whose "grandmother" was a cell
in a laboratory dish.
Devastating
blow
The
ultimate aim of the research is to help infertile couples have children. If the
same methods could be used in people then cells in skin could be turned into an
egg. Any resulting child would be genetically related to the mother.
However, Dr
Hayashi said that was still a distant prospect: "I must say that it is
impossible to adapt immediately this system to human stem cells, due to a
number of not only scientific reasons, but also ethical reasons."
He said
that the level of understanding of human egg development was still too limited.
There would also be questions about the long-term consequences on the health of
any resulting child.
Dr Evelyn
Telfer, from the University of Edinburgh, said: "It's an absolutely
brilliant paper - they made oocytes [eggs] from scratch and get live offspring.
I just thought wow! The science is quite brilliant."
However,
she warned that this had "no clinical relevance" as there were still
too many gaps in understanding about how human eggs developed.
"If
you can show it works in human cells it is like the Holy Grail of reproductive
biology," she added.
Prof Robert
Norman, from the University of Adelaide, said: "For many infertile
couples, finding they have no sperm or eggs is a devastating blow.
"This
paper offers light to those who want a child, who is genetically related to
them, by using personalised stem cells to create eggs that can produce an
offspring that appears to be healthy.
"It
also offers the potential for women to have their own children well past
menopause raising even more ethical issues.
"Application
to humans is still a long way off, but for the first time the goal appears to
be in sight."
Dr Allan
Pacey, from the British Fertility Society and the University of Sheffield,
said: "What is remarkable about this work is the fact that, although the
process is still quite inefficient, the offspring appeared healthy and were
themselves fertile as adults."
Related Articles:
"Recalibration of Knowledge" – Jan 14, 2012 (Kryon channelled by Lee Carroll) - (Subjects: Channelling, God-Creator, Benevolent Design, New Energy, Shift of Human Consciousness, (Old) Souls, Reincarnation, Gaia, Old Energies (Africa,Terrorists, Cuba, Iran, North Korea, Venezuela ... ), Weather, Rejuvenation, Akash, Nicolas Tesla / Einstein, Cold Fusion, Magnetics, Lemuria, Atomic Structure (Electrons, Particles, Polarity, Self Balancing, Magnetism, Higgs Boson), Entanglement, "Life is necessary for a Universe to exist and not the other way around", DNA, Humans (Baby getting ready, First Breath, Stem Cells, Embryonic Stem Cells, Rejuvenation), Global Unity, ... etc.) - (Text Version)
"... I want to define life for you - not biological life, but spiritual life. So for all those intellectuals, just hold on, for many won't like this. Spiritual life, as measured by Spirit, is when a Human has free choice. When is that? It's when they take their first breath. Not in utero. There will be those who will say, "That's wrong, that's wrong. The soul in the woman's body is alive!" Just wait. I'm talking about spiritually. That which Spirit sees, and it's when you come from the other side of the veil and take your first breath.
A child with the mother has no free choice. That child is linked to the choice of the mother until it is born. It is, indeed, a soul in preparation for free choice, and there are many attributes that are spiritual that we have discussed before about how that soul reacts. But now I'm discussing life with polarity [duality], free choice.
But let's discuss that "child inside" for a moment, for there is a process I want you to know about. I want to talk about 240 days into the pregnancy. At about that time, the child has perfect DNA. It hasn't taken its first breath. The DNA hasn't measured the energy of the planet yet, since it is contained. Did you realize that? Inside the womb is a perfect child. The child's DNA has all the attributes of the Akash and also the parent, but it's different in a way you have not been told. The DNA is 100% as designed.
The quantum instructions within the DNA are all talking to the biology of the child,, getting ready for the first breath. ..."
But let's discuss that "child inside" for a moment, for there is a process I want you to know about. I want to talk about 240 days into the pregnancy. At about that time, the child has perfect DNA. It hasn't taken its first breath. The DNA hasn't measured the energy of the planet yet, since it is contained. Did you realize that? Inside the womb is a perfect child. The child's DNA has all the attributes of the Akash and also the parent, but it's different in a way you have not been told. The DNA is 100% as designed.
The quantum instructions within the DNA are all talking to the biology of the child,, getting ready for the first breath. ..."
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